Plasma lipidomics to define the relationship of lipid metabolism with cardiometabolic risk factors and type 2 diabetes

Advances in liquid chromatography coupled with mass spectrometry over the recent years have revolutionized the detailed mapping of all lipid species contained in a biological sample. In this thesis, we comprehensively examined the relationship of lipid metabolism with cardiometabolic risk factors and outcomes utilizing three independent human cohorts: 1) the Australian Diabetes, Obesity and Lifestyle Study (AusDiab, n = 10,339); 2) a cohort of young adults recruited in Melbourne (n = 241) and 3) the Busselton Health Study (BHS, n = 4,207). The findings provide important insight into the role of lipids in health and disease.