Novel Role for Macrophage Migration Inhibitory Factor in the Regulation of Inflammation
thesisposted on 04.10.2020, 23:24 by SHAHRZAD ZAMANITAGHIZADEH RABE
Macrophage migration inhibitory factor (MIF) has been reported to be involved in inflammatory responses and wound healing. My findings indicated a significant correlation between MIF release and lytic but not apoptotic forms of cell death in THP-1 monocytes. In addition, a variable role for MIF in TLR4 induced type I interferon and TNF-α production was demonstrated in both macrophages and dendritic cells. In addition, a possible role for MIF tautomerase function was suggested. My findings for the first time shed new light on the novel role of MIF as a potential DAMP molecule.