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Novel Role for Macrophage Migration Inhibitory Factor in the Regulation of Inflammation

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thesis
posted on 04.10.2020, 23:24 by SHAHRZAD ZAMANITAGHIZADEH RABE
Macrophage migration inhibitory factor (MIF) has been reported to be involved in inflammatory responses and wound healing. My findings indicated a significant correlation between MIF release and lytic but not apoptotic forms of cell death in THP-1 monocytes. In addition, a variable role for MIF in TLR4 induced type I interferon and TNF-α production was demonstrated in both macrophages and dendritic cells. In addition, a possible role for MIF tautomerase function was suggested. My findings for the first time shed new light on the novel role of MIF as a potential DAMP molecule.

History

Principal supervisor

Nicole De Weerd

Year of Award

2020

Department, School or Centre

Molecular and Translational Sciences

Campus location

Australia

Course

Master of Biomedical Science

Degree Type

MPHIL

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