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Investigation of the effects of polymymyxins on sub-proteome and lipidome of K. pneumonia

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thesis
posted on 05.03.2019 by RAAD NEAMAH JASIM JASIM
The worldwide use of antibiotics results in the development of bacterial resistance, which poses a threat to the healthcare. With the dearth in the discovery and development of new antibiotics and rapid emergence of multidrug resistant (MDR) Gram-negative bacteria, the optimisation of clinically available antibiotics is highly warranted. For this critical situation, polymyxins, an “old-antibiotic” have been re-birthed as the last therapeutic option for the treatment of the serious bacterial infections. The administration of polymyxins as a single therapy is unlikely to achieve optimal and safe plasma concentration particularly with highly resistant pathogens. To overcome these limitations with polymyxins therapy, a combination with other antibiotics is an option. Better understanding the mode of actions of polymyxin combination therapy is crucially important to achieve maximum benefit.

History

Campus location

Australia

Principal supervisor

Tony Velkov

Additional supervisor 1

Jian Li

Additional supervisor 2

Mohammad Azad

Year of Award

2019

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

Exports

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Exports