Monash University
Raad Thesis 15-01-2019_Redacted.pdf (11.21 MB)
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Investigation of the effects of polymymyxins on sub-proteome and lipidome of K. pneumonia

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posted on 2019-03-05, 03:40 authored by RAAD NEAMAH JASIM JASIM
The worldwide use of antibiotics results in the development of bacterial resistance, which poses a threat to the healthcare. With the dearth in the discovery and development of new antibiotics and rapid emergence of multidrug resistant (MDR) Gram-negative bacteria, the optimisation of clinically available antibiotics is highly warranted. For this critical situation, polymyxins, an “old-antibiotic” have been re-birthed as the last therapeutic option for the treatment of the serious bacterial infections. The administration of polymyxins as a single therapy is unlikely to achieve optimal and safe plasma concentration particularly with highly resistant pathogens. To overcome these limitations with polymyxins therapy, a combination with other antibiotics is an option. Better understanding the mode of actions of polymyxin combination therapy is crucially important to achieve maximum benefit.


Campus location


Principal supervisor

Tony Velkov

Additional supervisor 1

Jian Li

Additional supervisor 2

Mohammad Azad

Year of Award


Department, School or Centre

Drug Delivery, Disposition and Dynamics


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences