L105 22029281 Post-examination Zoe Thesis 240924_Redacted.pdf (45.58 MB)

Investigation of Type I Interferon and Immune Signalling in Breast and Ovarian Cancer

Download (45.58 MB)
thesis
posted on 13.03.2019, 23:42 by ZOE REBECCA CHURCH MARKS
Cancer metastasis occurs as a result of poorly defined co-ordinated signals throughout the body. This thesis investigates the complex interactions between tumour cells and proteins called type I interferons (IFN), which can suppress tumour progression either directly or indirectly, by activating immune responses. My results show that these signals are detectable in blood during the spread of breast cancer, reflecting immune changes occurring in primary tumours and metastatic potential. Additionally, this work reveals an unusual type I IFN, IFN, plays a role in suppressing ovarian cancer development and further, has therapeutic potential against the spread of this cancer.

History

Principal supervisor

Paul Hertzog

Additional supervisor 1

Nollaig Bourke

Year of Award

2018

Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

Exports