Investigation of Type I Interferon and Immune Signalling in Breast and Ovarian Cancer

Cancer metastasis occurs as a result of poorly defined co-ordinated signals throughout the body. This thesis investigates the complex interactions between tumour cells and proteins called type I interferons (IFN), which can suppress tumour progression either directly or indirectly, by activating immune responses. My results show that these signals are detectable in blood during the spread of breast cancer, reflecting immune changes occurring in primary tumours and metastatic potential. Additionally, this work reveals an unusual type I IFN, IFN, plays a role in suppressing ovarian cancer development and further, has therapeutic potential against the spread of this cancer.