Monash University
L105 22029281 Post-examination Zoe Thesis 240924_Redacted.pdf (45.58 MB)

Investigation of Type I Interferon and Immune Signalling in Breast and Ovarian Cancer

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posted on 2019-03-13, 23:42 authored by ZOE REBECCA CHURCH MARKS
Cancer metastasis occurs as a result of poorly defined co-ordinated signals throughout the body. This thesis investigates the complex interactions between tumour cells and proteins called type I interferons (IFN), which can suppress tumour progression either directly or indirectly, by activating immune responses. My results show that these signals are detectable in blood during the spread of breast cancer, reflecting immune changes occurring in primary tumours and metastatic potential. Additionally, this work reveals an unusual type I IFN, IFN, plays a role in suppressing ovarian cancer development and further, has therapeutic potential against the spread of this cancer.


Principal supervisor

Paul Hertzog

Additional supervisor 1

Nollaig Bourke

Year of Award


Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Molecular and Translational Science (Hudson Institute)

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences