Preissner_12271039_PhD_thesis_FINAL.pdf (18.34 MB)

Dynamic X-ray imaging of mice in vivo to investigate lung function and structure in ventilator-induced lung injury

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thesis
posted on 22.05.2020 by MELISSA HELENE PREISSNER
When the lungs begin to fail, mechanical ventilation is a life-saving intervention. However, mechanical ventilation can also damage the delicate structures in the lung, known as ventilator-induced lung injury. The risk increases substantially when the lungs are in a pathological state, such as with acute respiratory distress syndrome, where hospital mortality remains unacceptably high. In this PhD thesis, a recent development in laboratory-based, dynamic X-ray CT imaging, combined with customised image analysis, is used to investigate changes to the delicate structures in the mechanically-ventilated mouse lung, in order to better understand ventilator-induced lung injury.

History

Campus location

Australia

Principal supervisor

Stephen Eric Thomas Dubsky

Year of Award

2020

Department, School or Centre

Mechanical and Aerospace Engineering

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Exports

Exports