Dynamic X-ray imaging of mice in vivo to investigate lung function and structure in ventilator-induced lung injury
thesisposted on 22.05.2020 by MELISSA HELENE PREISSNER
In order to distinguish essays and pre-prints from academic theses, we have a separate category. These are often much longer text based documents than a paper.
When the lungs begin to fail, mechanical ventilation is a life-saving intervention. However, mechanical ventilation can also damage the delicate structures in the lung, known as ventilator-induced lung injury. The risk increases substantially when the lungs are in a pathological state, such as with acute respiratory distress syndrome, where hospital mortality remains unacceptably high. In this PhD thesis, a recent development in laboratory-based, dynamic X-ray CT imaging, combined with customised image analysis, is used to investigate changes to the delicate structures in the mechanically-ventilated mouse lung, in order to better understand ventilator-induced lung injury.