L137 PhD_Thesis_Andrew_Guy_2018_Redacted.pdf (10.74 MB)
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Computational approaches for examining the impact of protein structure on malaria immunity

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posted on 2019-03-21, 00:05 authored by ANDREW JOHN GUY
This thesis examines the impact of protein three-dimensional (3D) structure on the development of adaptive immunity to malaria. This work has identified new bioinformatics approaches that highlight the prevalence and importance of disordered proteins, as well as new approaches for mapping critical characteristics onto protein 3D structures. These approaches have been applied to specific vaccine candidates, highlighting important regions to assist with vaccine design.


Principal supervisor

Paul Ramsland

Additional supervisor 1

Jack Richards

Additional supervisor 2

James Beeson

Year of Award


Department, School or Centre

Immunology - Alfred

Additional Institution or Organisation

Burnet Institute

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences