DC
Publications
- Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.
- The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells.
- A profile of lipid dysregulation in Harlequin Ichthyosis
- Topical Aminosalicylic Acid Improves Keratinocyte Differentiation in an Inducible Mouse Model of Harlequin Ichthyosis
- Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy.
- BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage
- P53 activity contributes to defective interfollicular epidermal differentiation in hyperproliferative murine skin
- INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability
- BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor under Steady-State Conditions.
- Keratin 76 is required for tight junction function and maintenance of the skin barrier.
- Fetal inhibition of inflammation improves disease phenotypes in Harlequin Ichthyosis.
- Regulation of the transcriptional coactivator FHL2 licenses activation of the androgen receptor in castrate-resistant prostate cancer.
- SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis.
- Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy.
- Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis
- Regulation of PDGFC signalling and extracellular matrix composition by FREM1 in mice.
- FHL3 binds MyoD and negatively regulates myotube formation.
- FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly.
- Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation.
- c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor/p53 axis.
- Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.
- Four and a half LIM protein 1 gene mutations cause four distinct human myopathies: a comprehensive review of the clinical, histological and pathological features.
- CBE1 is a manchette and mitochondria associated protein with a potential role in somatic cell proliferation
- A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder
- ABCA12 regulates insulin secretion from β-cells.
- AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease.
- Deletion of Aurora kinase A prevents the development of polycystic kidney disease in mice
- Modulating inflammation with interleukin 37 treatment ameliorates murine Autosomal Dominant Polycystic Kidney Disease
- Disrupted glucocorticoid receptor cell signalling causes a ciliogenesis defect in the fetal mouse renal tubule
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Co-workers & collaborators
- IS
Ian Smyth
- AZ
Allara Zylberberg
- MS
Ming Shen Tham