Denny Cottle

Publications

• Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.
• The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells.
• A profile of lipid dysregulation in Harlequin Ichthyosis
• Topical Aminosalicylic Acid Improves Keratinocyte Differentiation in an Inducible Mouse Model of Harlequin Ichthyosis
• Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy.
• BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage
• P53 activity contributes to defective interfollicular epidermal differentiation in hyperproliferative murine skin
• INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability
• BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor under Steady-State Conditions.
• Keratin 76 is required for tight junction function and maintenance of the skin barrier.
• Fetal inhibition of inflammation improves disease phenotypes in Harlequin Ichthyosis.
• Regulation of the transcriptional coactivator FHL2 licenses activation of the androgen receptor in castrate-resistant prostate cancer.
• SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis.
• Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy.
• Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis
• Regulation of PDGFC signalling and extracellular matrix composition by FREM1 in mice.
• FHL3 binds MyoD and negatively regulates myotube formation.
• FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly.
• Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation.
• c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor/p53 axis.
• Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.
• Four and a half LIM protein 1 gene mutations cause four distinct human myopathies: a comprehensive review of the clinical, histological and pathological features.
• CBE1 is a manchette and mitochondria associated protein with a potential role in somatic cell proliferation
• A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder
• ABCA12 regulates insulin secretion from β-cells.
• AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease.
• Deletion of Aurora kinase A prevents the development of polycystic kidney disease in mice
• Modulating inflammation with interleukin 37 treatment ameliorates murine Autosomal Dominant Polycystic Kidney Disease