CB
Charles Bayly-Jones
Structural biologist (Biological sciences; Biomedical and clinical sciences; Medical biochemistry and metabolomics; Bioinformatics and computational biology; Biochemistry and cell biology; Structural biology (incl. macromolecular modelling))
Melbourne, Australia
Publications
- The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1
- The mystery behind membrane insertion: A review of the complement membrane attack complex
- Ancient but Not Forgotten: New Insights Into MPEG1, a Macrophage Perforin-Like Immune Effector
- The first transmembrane region of complement component-9 acts as a brake on its self-assembly
- Structural and functional characterisation of MACPF proteins in immunity
- Challenges and approaches to studying pore-forming proteins
- The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1
- Mining folded proteomes in the era of accurate structure prediction
- The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9
- Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism
- Single-molecule analysis of the entire perfringolysin O pore formation pathway
- Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor
- The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9
- Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically "actionable" signalling axis in triple negative breast cancer
- Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically ‘actionable’ signalling axis in triple negative breast cancer
- LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR
- Structure of the human TSC:WIPI3 lysosomal recruitment complex
- Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer
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Co-workers & collaborators
- CL
Chris Lupton
- RS
Ralf Schittenhelm
- GJ
Gareth Jones
- YC
Yonggang Chang
- LD
Laura D'Andrea
- AE
Andrew M. Ellisdon.