Charles Bayly-Jones

Publications

• The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1
• The mystery behind membrane insertion: A review of the complement membrane attack complex
• Ancient but Not Forgotten: New Insights Into MPEG1, a Macrophage Perforin-Like Immune Effector
• The first transmembrane region of complement component-9 acts as a brake on its self-assembly
• Structural and functional characterisation of MACPF proteins in immunity
• Challenges and approaches to studying pore-forming proteins
• The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1
• Mining folded proteomes in the era of accurate structure prediction
• The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9
• Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism
• Single-molecule analysis of the entire perfringolysin O pore formation pathway
• Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor
• The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9
• Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically "actionable" signalling axis in triple negative breast cancer
• Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically ‘actionable’ signalling axis in triple negative breast cancer
• LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR
• Structure of the human TSC:WIPI3 lysosomal recruitment complex
• Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer