Cameron Nowell

Publications

• Practical and low cost whole-organism motility assay: A step-by-step protocol
• A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging
• Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C
• Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling.
• Inhibition of the KCa3.1 Channel Alleviates Established Pulmonary Fibrosis in a Large Animal Model.
• Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors
• Loss of the Wnt receptor Frizzled7 in the gastric epithelium is deleterious and triggers rapid repopulation in vivo
• Emulsions Containing Optimum Cow Milk Fat and Canola Oil Mixtures Replicate the Lipid Self-assembly of Human Breast Milk during Digestion
• Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedema
• High throughput, quantitative analysis of human osteoclast differentiation and activity
• Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide
• Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia
• Histological changes in the umbilical artery following severe chorioamnionitis and funisitis may be indicative of early atherosclerosis.
• High-content siRNA 3D co-cultures to identify myoepithelial cell-derived breast cancer suppressor proteins
• In Vivo Formation of Cubic Phase in Situ after Oral Administration of Cubic Phase Precursor Formulation Provides Long Duration Gastric Retention and Absorption for Poorly Water-Soluble Drugs
• Cellular uptake and localization of polymyxins in renal tubular cells using rationally designed fluorescent probes
• Condensin I and II behaviour in interphase nuclei and cells undergoing premature chromosome condensation
• Polymyxin B causes DNA damage in HK-2 cells and mice
• Potential toxicity of polymyxins in human lung epithelial cells
• Ligand-dependent modulation of G protein conformation alters drug efficacy
• Systematic high-content genome-wide RNAi screens of endothelial cell migration and morphology
• Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide
• A Nonionic Polyethylene Oxide (PEO) Surfactant Model
• Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts
• Inflammation-associated changes in DOR expression and function in the mouse colon
• Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion
• Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery
• Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages
• A fresh shine on cystic fibrosis inhalation therapy
• Correction to
• Mouse models for dominant dystrophic epidermolysis bullosa carrying common human point mutations recapitulate the human disease
• Combination of agrin and laminin increase acetylcholine receptor clustering and enhance functional neuromuscular junction formation In vitro
• Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination
• Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling
• A novel segmental challenge model for bleomycin-induced pulmonary fibrosis in sheep
• Differences in the cellular composition of small versus large uterine fibroids
• A three-dimensional lymphatic endothelial cell tube formation assay to identify novel kinases involved in lymphatic vessel remodeling
• Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling
• Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation
• Histological changes in the umbilical artery following severe chorioamnionitis and funisitis may be indicative of early atherosclerosis
• Multi-Clonal Live SARS-CoV-2 In Vitro Neutralization by Antibodies Isolated from Severe COVID-19 Convalescent Donors
• Expansion of the phenotypic spectrum of de novo missense variants in kinesin family member 1A ( KIF1A )
• Assessing the cellular toxicity of peptide inhibitors of intracellular protein-protein interactions by microinjection
• Regulation of oogenesis in the queen honey bee (Apis mellifera)
• Cover, Volume 41, Issue 10
• Machine Learning for the Fast and Accurate Assessment of Fitness in Coral Early Life History
• Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity
• Depolymerization of hyaluronan using PEGylated human recombinant hyaluronidase promotes nanoparticle tumor penetration
• Air-Liquid-Interface Differentiated Human Nose Epithelium: A Robust Primary Tissue Culture Model of SARS-CoV-2 Infection
• Resolving subcellular pH with a quantitative fluorescent lifetime biosensor
• A role for bone morphogenetic protein-4 in lymph node vascular remodeling and primary tumor growth
• NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells
• Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak,and Bax and inhibited by Bcl-2 and Mcl-1
• Identification of a Wnt-induced protein complex by affinity proteomics using an antibody that recognizes a sub-population of β-catenin
• Fas regulates neutrophil lifespan during viral and bacterial infection
• Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration
• Examining the gastrointestinal transit of lipid-based liquid crystalline systems using whole-animal imaging
• IDH1 mutation is associated with seizures and protoplasmic subtype in patients with low-grade gliomas
• The wiggle index: An open source bioassay to assess sub-lethal insecticide response in Drosophila melanogaster
• Plasminogen fragmentation and increased production of extracellular matrix-degrading proteinases are associated with serous epithelial ovarian cancer progression
• Low cost whole-organism screening of compounds for anthelmintic activity
• Vascular endothelial growth factor-d modulates caliber and function of initial lymphatics in the dermis
• In vivo real-time visualization of leukocytes and intracellular hydrogen peroxide levels during a zebrafish acute inflammation assay
• β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion
• Neutrophil-delivered myeloperoxidase dampens the hydrogen peroxide burst after tissue wounding in zebrafish
• Axonally derived matrilin-2 induces proinflammatory responses that exacerbate autoimmune neuroinflammation
• Nucleocytoplasmic Coagulation: An Injury-Induced Aggregation Event that Disulfide Crosslinks Proteins and Facilitates Their Removal by Plasmin
• Detection and quantifi cation of intracellular signaling using fret-based biosensors and high content imaging
• Analysis of cellular phosphatidylinositol (3,4,5)-trisphosphate levels and distribution using confocal fluorescent microscopy
• Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5+ stem cells
• Follistatin is essential for normal postnatal development and function of mouse oviduct and uterus
• Differential use of autophagy by primary dendritic cells specialized in cross-presentation
• Divergent lymphocyte signalling revealed by a powerful new tool for analysis of time-lapse microscopy
• Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction
• Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5+ stem cells
• PI3K-alpha translocation mediates nuclear PtdIns(3,4,5)P3 effector signaling in colorectal cancer
• Small extracellular vesicles promote invadopodia activity in glioblastoma cells in a therapy-dependent manner
• PI3Kα Translocation Mediates Nuclear PtdIns(3,4,5)P3 Effector Signaling in Colorectal Cancer
• A novel device for investigating structure-function relationships and mechanoadaptation of biological tissues
• Bio‐Mimicking Brain Vasculature to Investigate the Role of Heterogeneous Shear Stress in Regulating Barrier Integrity
• A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel KV1.3
• The lung employs an intrinsic surfactant-mediated inflammatory response for viral defense
• A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel KV1.3
• Systematic investigation of metabolic oligosaccharide engineering efficiency in intestinal cells using a dibenzocyclooctyne‐monosaccharide conjugate
• Beta-blockade enhances anthracycline control of metastasis in triple-negative breast cancer
• Hydrophobicity Regulates the Cellular Interaction of Cyanine5-Labeled Poly(3-hydroxypropionate)-Based Comb Polymers
• Reproductive plasticity and oogenesis in the queen honey bee (Apis mellifera)
• Enhanced nitric oxide production by macrophages treated with a cell-penetrating peptide conjugate
• The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection
• The γH2AX DSB marker may not be a suitable biodosimeter to measure the biological MRT valley dose
• No observed effect on brain vasculature of Alzheimer’s disease-related mutations in the zebrafish presenilin 1 gene
• Decreased Orexin Receptor 1 mRNA Expression in the Locus Coeruleus in Both Tau Transgenic rTg4510 and Tau Knockout Mice and Accompanying Ascending Arousal System Tau Invasion in rTg4510
• Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice
• Physiological and pharmacological impact of oxytocin on epididymal propulsion during the ejaculatory process in rodents and men
• A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes
• Trisulfide linked cholesteryl PEG conjugate attenuates intracellular ROS and collagen-1 production in a breast cancer co-culture model
• Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A1 Receptor in Living Cells
• Emulsions containing optimum cow milk fat and canola oil mixtures replicate the lipid self-assembly of human breast milk during digestion
• In the Loop: Extrastriatal Regulation of Spiny Projection Neurons by GPR52
• Expansion of the phenotypic spectrum of de novo missense variants in kinesin family member 1A ( KIF1A )
• Endometrial uNK cell counts do not predict successful implantation in an IVF population
• Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases
• Microfluidic preparation of drug-loaded PEGylated liposomes, and the impact of liposome size on tumour retention and penetration
• A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain
• Controlling the size and shape of liposomal ciprofloxacin nanocrystals by varying the lipid bilayer composition and drug to lipid ratio
• Cell quiescence correlates with enhanced glioblastoma cell invasion and cytotoxic resistance
• Visualising functional 5-HT3 receptors containing A and C subunits at or near the cell surface
• Intra-articular Injection of a B Cell Depletion Antibody Enhances Local Exposure to the Joint-Draining Lymph Node in Mice with Collagen-Induced Arthritis
• Direct Comparison of Standard Transmission Electron Microscopy and Cryogenic-TEM in Imaging Nanocrystals Inside Liposomes
• Carboxylated Cy5-Labeled Comb Polymers Passively Diffuse the Cell Membrane and Target Mitochondria
• Characterisation and 3D structure of melanomacrophage centers in shorthorn sculpins (Myoxocephalus scorpius)
• Biologically active constituents of the secretome of human W8B2+ cardiac stem cells
• Rosiglitazone and a β3-adrenoceptor agonist are both required for functional browning of white adipocytes in culture
• MACROD2 haploinsufficiency impairs catalytic activity of PARP1 and promotes chromosome instability and growth of intestinal tumors
• Secondary Self-Assembly of Supramolecular Nanotubes into Tubisomes and Their Activity on Cells
• Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain
• Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment
• Stress hormone signaling through β-adrenergic receptors regulates macrophage mechanotype and function
• Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling
• The PPARγ agonist rosiglitazone promotes the induction of brite adipocytes, increasing β-adrenoceptor-mediated mitochondrial function and glucose uptake
• Divergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity
• LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins
• Using a Multiplex Nucleic Acid in situ Hybridization Technique to Determine HCN4 mRNA Expression in the Adult Rodent Brain
• Rapid Assessment of Nanoparticle Extravasation in a Microfluidic Tumor Model
• Influence of Casein and Milk Phospholipid Emulsifiers on the Digestion and Self-Assembled Structures of Milk Lipids
• Functionalisation of brush polyethylene glycol polymers with specific lipids extends their elimination half-life through association with natural lipid trafficking pathways
• Re-coding of G protein-coupled receptor signaling enables emergent cellular behavior.
• NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils
• Re-coding of G protein-coupled receptor signaling enables emergent cellular behavior
• TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility
• The pro‐resolving mediator, annexin A1 regulates blood pressure, and age‐associated changes in cardiovascular function and remodeling
• Novel formylpeptide receptor 1/2 agonist limits hypertension-induced cardiovascular damage