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pH-responsive alginate-based composite hydrogel beads for oral insulin delivery

thesis
posted on 01.10.2017 by HUI PENG LIM
This research attempts to develop a pH-responsive alginate-based composite hydrogel beads for encapsulation and controlled delivery of oral insulin aspart through incorporation of κ-carrageenan as a reinforcement polymer and hydrophobic modification of alginate polymer. The alginate/κ-carrageenan composite hydrogel beads were able to fully retain the insulin in conditions mimicking the stomach and release the insulin in conditions mimicking the intestine at a constant rate. Bioactivity of insulin aspart in the composite hydrogel beads after acid-pretreatment was higher than that of pure alginate beads. The results suggest that the alginate/κ-carrageenan composite hydrogel beads is a promising system for oral insulin delivery.

History

Campus location

Malaysia

Principal supervisor

Chan Eng Seng

Year of Award

2017

Department, School or Centre

School of Engineering (Monash University Malaysia)

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Engineering

Exports

Exports