Embargoed and Restricted Access
Reason: Under embargo until May 2019. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
microRNA stability in innate immunity
thesisposted on 2018-05-07, 01:24 authored by CHARLOTTE NEJAD
MicroRNAs (miRNAs) are small non-coding RNAs, which are involved in the regulation of almost every cellular and developmental process. Dysregulation of miRNA intracellular levels participate to human pathologies such as autoimmune diseases. My research examines miRNA turnover, a critical feature impacting their regulatory activity. I found that the pro-inflammatory miRNA-221 and 222 are rapidly degraded after activation of the innate immune system, possibly impacting inflammatory responses. Significantly, the ability to selectively promote degradation of miRNAs was able to be used as a biomarker, suggesting the importance of miRNA turnover in the development of small RNA therapeutics.