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microRNA stability in innate immunity

thesis
posted on 07.05.2018, 01:24 authored by CHARLOTTE NEJAD
MicroRNAs (miRNAs) are small non-coding RNAs, which are involved in the regulation of almost every cellular and developmental process. Dysregulation of miRNA intracellular levels participate to human pathologies such as autoimmune diseases. My research examines miRNA turnover, a critical feature impacting their regulatory activity. I found that the pro-inflammatory miRNA-221 and 222 are rapidly degraded after activation of the innate immune system, possibly impacting inflammatory responses. Significantly, the ability to selectively promote degradation of miRNAs was able to be used as a biomarker, suggesting the importance of miRNA turnover in the development of small RNA therapeutics.

History

Principal supervisor

Michael Gantier

Year of Award

2018

Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences