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(epi)genetic and (epi)transcriptomic gene regulation in the maintenance of embryonic stem cell state

thesis
posted on 03.01.2022, 22:56 by MAJID MEHRAVAR
This study addresses some outstanding issues in the epigenetics (DNA and histone modifications) and epitranscriptomics (RNA modifications) fields for gene regulation and embryonic stem cell (ESC) state maintenance that have not been resolved yet. These comprise: i) Investigate combinatorial gene regulatory functions of all histone-demethylases (HDMs, a class of epigenetic regulators) in murine ESCs. ii) Identify the novel m6A RNA methylation-reader/binding proteins and dissect their roles in maintaining the murine ESC state. iii) Examine underlying mechanisms that link epigenetic and epitranscriptomic pathways for gene regulation to maintain the ESC state.

History

Principal supervisor

Partha Das

Additional supervisor 1

Robin Hobbs

Year of Award

2022

Department, School or Centre

Anatomy and Developmental Biology

Additional Institution or Organisation

Biomedicine Discovery Institute (BDI) / Anatomy and Developmental Biology Department

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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