Embargoed and Restricted Access
Reason: Under embargo until 31 August 2025. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.
Zebrafish models for studying cell-autonomous functions of neutrophils and macrophages
Timely arrival and departure of white blood cells are required for proper tissue repair after injury. The migratory white blood cells, specifically neutrophils and macrophages, are the earliest to arrive the sites of tissue injury. To arrive or leave these sites, neutrophils and macrophages employ several cell-specific (intrinsic) mechanisms. They are equally influenced by the ever-changing external environment (extrinsic) through which they move. Distinguishing between these cell-intrinsic and extrinsic influences on white blood cell migration requires definitive in vivo models. This thesis describes new zebrafish models for evaluating cell-intrinsic and extrinsic determinants of white blood cell migration and function.
