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Virulence characteristics and diagnostic implications of invasive Staphylococcus aureus disease

posted on 23.07.2018, 03:51 by CARA LOUISE NETHERCOTT
Staphylococcus aureus is a pathogenic bacterium of significant global concern. It is essential to understand the molecular characteristics associated with invasive S. aureus infections and develop tools for rapid and accurate diagnosis of infections cause by multidrug resistant strains. This thesis investigates molecular characteristics associated with infective endocarditis, characterises a leukotoxin that acts as a direct neutrophil chemoattractant and examines infrared spectroscopy as a potential diagnostic tool to identify antibiotic resistance. This work contributes to the knowledge of S. aureus virulence, host cell interactions and antimicrobial resistance, which can help monitor the spread of this pathogen and combat infections.


Principal supervisor

Anton Peleg

Additional supervisor 1

Gerald Murray

Additional supervisor 2

Jhih-Hang Jiang

Year of Award


Department, School or Centre


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences