Monash University

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Reason: Under embargo until October 2021. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Viral targeting of STAT3: Novel mechanisms of immune evasion

posted on 2020-10-05, 05:12 authored by ANGELA ROSE HARRISON
Ebola virus and lyssaviruses are global health threats that cause lethal disease in humans. The ability of these viruses to evade immunity is critical to infection, but the underlying mechanisms are incompletely understood. This thesis identifies novel immune evasion strategies whereby viral targeting of the host protein STAT3 suppresses responses to interleukin-6 cytokines, critical players in inflammation and immunity. The thesis also reveals novel exploitation of host trafficking machinery by Ebola virus to transport its immune evasion protein between important cellular sites. These data provide fundamental insights into infection, and identify potential targets for the development of antivirals and vaccines.


Principal supervisor

Gregory Moseley

Additional supervisor 1

Nicholas Williamson

Year of Award


Department, School or Centre

School of Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences