ChanKYY_PhD Thesis.pdf (15.49 MB)
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Ventilation-Induced Brain Injury in Preterm Neonates: Mechanisms and Potential Therapies

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posted on 03.11.2020, 11:42 by YAN YEE KYRA CHAN
Premature babies often have trouble breathing at birth. Supporting breathing with mechanical ventilation is lifesaving but unfortunately can injure their immature brains. I aimed to understand brain injury from ventilation immediately at birth and within the neonatal intensive care unit (hours to days after birth), using fetal sheep models. I investigated how ventilation in the delivery room affects the brain and if umbilical cord blood cells are a potential therapy. I also examined what brain changes can be detected after prolonged ventilation. My findings will aid development of interventions to benefit our tiniest babies who need help breathing.


Principal supervisor

Graeme Roger Polglase

Additional supervisor 1

Suzanne Lee Miller

Additional supervisor 2

Vanesa Stojanovska

Year of Award


Department, School or Centre

Obstetrics and Gynaecology

Additional Institution or Organisation

The Ritchie Centre, Hudson Institute of Medical Research

Campus location



Doctor of Philosophy

Degree Type