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Venom Proteome of Malaysian Pit Vipers (Calloselasma rhodostoma and Cryptelytrops purpureomaculatus) and Identification of Selected Proteins with Potential Anti-cancer Activity on Human Colon Cancer Cells
thesis
posted on 2018-01-05, 00:16 authored by SYAFIQ ASNAWI BIN ZAINAL ABIDINColon cancer is one of the most common cancer deaths in the world including Malaysia. Current therapeutic approaches are known to have serious side effects; therefore research into alternative strategies such as from natural resources is necessary. This present study was able to identify selected proteins with anti-cancer activities from the venom of Calloselasma rhodostoma and Cryptelytrops purpureomaculatus. The proteins demonstrated selective cytotoxic activity and induction of apoptosis in human colon cancer cells. These data provides evidence on the anti-cancer activity of several proteins from the venom of Malaysian pit vipers for therapeutic intervention of human colon cancer.
History
Principal supervisor
Rakesh NaiduAdditional supervisor 1
Iekhsan OthmanAdditional supervisor 2
Ezharul Hoque ChowdhuryAdditional supervisor 3
Pathmanathan RajaduraiYear of Award
2018Department, School or Centre
Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)Campus location
MalaysiaCourse
Doctor of PhilosophyDegree Type
DOCTORATEFaculty
Faculty of Medicine Nursing and Health SciencesUsage metrics
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Keywords
proteomicscolon cancercalloselasma rhodostomacryptelytrops purpuromaculatusanticancerProteins and PeptidesCancerCancer Therapy (excl. Chemotherapy and Radiation Therapy)Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)Proteomics and Intermolecular Interactions (excl. Medical Proteomics)
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