Embargoed and Restricted Access
Reason: Under embargo until 31 July 2025. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.
Understanding the role of the intestinal epithelium in paediatric inflammatory bowel disease
Inflammatory bowel disease is a multifactorial disease, with more than 6.8million cases reported worldwide. It is characterised by inflammation occurring in the gastrointestinal tract, where there are currently no cures available. This study utilised patient biopsy samples to derive 3D intestinal cell cultures to investigate differences in intestinal epithelial stem cells. Bacteria was also isolated from these biopsy samples leading to identification of bacterial candidates associated with control or inflammatory bowel disease cases. Bacteria were introduced to the intestinal cultures to determine the impact of bacterial-mediated processes on inflammation and stem cell function in inflammatory bowel disease.
