Monash University

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Understanding the role of regulatory T cells in tissue repair and regeneration

posted on 2023-09-04, 06:50 authored by BHAVANA NAYER
Regulatory T cells, or Tregs, which are an anti-inflammatory immune cell subset, play a key role in tissue healing after injury. In this project, we characterised the role of Tregs in multiple mouse injury models, including bone, muscle and skin injuries. We found that delivering Tregs into injured mouse tissues accelerated their healing, by producing anti-inflammatory factors that promoted macrophages to switch to a pro-repair state. Treg delivery also reduced the accumulation of inflammatory cells in the injured tissue. Overall, this demonstrated the potential of using Tregs as a novel cell-based therapy to improve tissue repair and regeneration.


Principal supervisor

Mikael Martino

Additional supervisor 1

Jean Tan

Additional supervisor 2

Ajithkumar Vasanthakumar

Year of Award


Department, School or Centre

Australian Regenerative Medicine Institute (ARMI)

Additional Institution or Organisation

Australian Regenerative Medicine Institute

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses