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Understanding the role of podocytes and podocyte depletion in the therapeutics of chronic kidney disease.
thesis
posted on 2021-12-08, 00:46 authored by AGAMPODI NETHALIE NATASHA DE ZOYSAChronic kidney disease (CKD) affects about 10% of the global population, and may sometimes progress to end stage kidney disease (ESKD). Majority of CKD occurs due to loss or injury of cells called podocytes. Podocytes resemble an octopus as they have tentacle-like extensions that interact with other extensions from nearby podocytes to form the filtration barrier. These cells are vital to the filtering system of the kidney. The broad hypothesis investigated in this thesis is that podocyte loss plays a crucial role in the progression of CKD, and that podocytes are key targets in therapies designed to halt progression of CKD.
