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Understanding the role of podocytes and podocyte depletion in the therapeutics of chronic kidney disease.

posted on 08.12.2021, 00:46 by AGAMPODI NETHALIE NATASHA DE ZOYSA
Chronic kidney disease (CKD) affects about 10% of the global population, and may sometimes progress to end stage kidney disease (ESKD). Majority of CKD occurs due to loss or injury of cells called podocytes. Podocytes resemble an octopus as they have tentacle-like extensions that interact with other extensions from nearby podocytes to form the filtration barrier. These cells are vital to the filtering system of the kidney. The broad hypothesis investigated in this thesis is that podocyte loss plays a crucial role in the progression of CKD, and that podocytes are key targets in therapies designed to halt progression of CKD.


Principal supervisor

Luise Anne Cullen-mcewen

Additional supervisor 1

Professor John Bertram

Additional supervisor 2

Professor David Nikolic-Paterson

Year of Award


Department, School or Centre

Anatomy and Developmental Biology

Additional Institution or Organisation

Biomedicine Discovery Institute

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences

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