Understanding the role of Candida albicans Rpn4 in proteasome assembly and its link to cell membrane stress

Candida albicans is a highly adaptable human fungal pathogen that can cause superficial to serious infections. Incidences of antifungal resistance are increasing and pose a major concern to our healthcare system. This thesis examines the molecular components and pathways which enables Candida albicans to develop resistance and tolerance following exposure to antifungals.