Monash University
Final Thesis_LCauchi.pdf (14.62 MB)

Understanding the molecular mechanism of male infertility using flies, mice, and humans

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posted on 2022-03-15, 02:54 authored by LACHLAN MARK CAUCHI
Male infertility is a complex disorder with a strong genetic contribution. The work in this thesis used two model organisms, the vinegar fly Drosophila melanogaster and the mouse, to discover novel genes involved in spermatogenesis. Two candidate genes found to be mutated in infertile patients were found to be essential for Drosophila sperm production. One of these was further analysed by generating a knockout mouse. The function of intracellular zinc transport in male fertility was also examined by manipulation of zinc transporter genes in the Drosophila testis; several members of this gene family were shown to cause infertility when mutated.


Campus location


Principal supervisor

Richard Burke

Additional supervisor 1

Moira O'Bryan

Additional supervisor 2

Daniela Fietz

Year of Award


Department, School or Centre

Biological Sciences

Additional Institution or Organisation

Justus Liebig Univeristy Giessen, in Giessen, Hesse, Germany


Doctor of Philosophy (Monash-JLU Giessen)

Degree Type



Faculty of Science

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    Faculty of Science Theses