Thesis_final.pdf (79.13 MB)

Understanding structure and activation of GLP-1R

Download (79.13 MB)
thesis
posted on 01.03.2021, 06:57 by XIN ZHANG
In this thesis, single particle cryo-electron microscopy was used to determine molecular details of the structure and dynamic motion of a major diabetes and obesity therapeutic target, the GLP-1 receptor. Studying structures of the receptor bound to both clinically approved and tool activators with distinct properties, the work provided critical insight into how current drugs work. This thesis work will be instrumental in development of the next generation of drugs targeting the GLP-1 receptor.

History

Campus location

Australia

Principal supervisor

Patrick Sexton

Additional supervisor 1

Denise Wootten

Year of Award

2021

Department, School or Centre

Drug Discovery Biology

Course

Doctor of Philosophy

Degree Type

DOCTORATE