Understanding physicochemical properties of Essential oils relevant to intake by inhalation for optimising neuropsychological efficacy

Inhaled Essential oils display good bioavailability to the brain. However, despite their promising potential for brain-related therapies, the dose is usually not controlled and Essential oils are poorly optimized for efficacy. The project examined the physicochemical factors that control the volatility of Essential oils and developed methodologies for predicting and controlling inhalable dose. Mechanisms by which Essential oils affect depression and anxiety were explored including pathways mediated by neurotransmitter receptor binding and neurochemical processes influenced by the signalling molecule, hydrogen peroxide. The research lays the groundwork for developing personalised dose-control of Essential oils for optimising therapeutic applications.