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Reason: Under embargo until 20 September 2024. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Understanding mechanisms of disease evolution in melanoma
thesisposted on 2023-09-20, 06:02 authored by MALAKA SRINETH PERERA AMERATUNGA
Melanoma is a type of skin cancer that can be lethal. This study found that whilst melanoma is usually pigmented, depigmentation occurs as melanoma progresses, suggesting that depigmented cells outcompete pigmented cells, and that this is linked to expression of a protein called AXL. By modifying AXL levels and developing systems to evaluate how melanoma cells compete with one another, it was shown that AXL does not by itself reliably affect pigmentation, and that the role it plays in melanoma progression might vary from patient to patient. The findings provide insight into complex mechanisms of how melanoma cells compete and evolve as the disease progresses.