Understanding IRAP inhibition using diverse substrates, inhibitors and mutagenesis

Insulin-regulated aminopeptidase (IRAP) controls key body functions and involved in different disease states by processing a range of substrates. My research aims to study the biochemistry of IRAP utilising a series of novel substrates and inhibitors. These reagents, together with studies of mutated IRAP enzymes, distinguish key characteristics of ligand binding that distinguish different classes of both substrates and inhibitors. The generated data help unlock the fine details of IRAP function that could power future drug discovery efforts.