Monash University
Thesis_DZ_amended.pdf (27.16 MB)

Uncovering the immunoregulatory mechanisms underlying extravascular mesenchymal stromal cell treatment

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posted on 2023-06-14, 23:44 authored by DI ZHENG
Mesenchymal stromal cells (MSCs) possess therapeutic benefits in treating inflammatory diseases. However, the mechanisms underlying their therapeutic effects are unclear, hindering the clinical translation of MSC therapy. This project investigated the mode of action of MSC therapy following local administration. MSCs exhibited local protective effects and remote anti-inflammatory effects without migrating away from the injection site. This project identified the lymph node as a key location where MSCs initiated their local and remote effects by inducing immunoregulatory cells. Findings from this project advanced our understanding of the mechanisms of MSC therapy and will aid in effective clinical translation.


Principal supervisor

Tracy Shu Ping Heng

Additional supervisor 1

Laurence Meagher

Additional supervisor 2

Graham Vesey

Year of Award


Department, School or Centre

Anatomy and Developmental Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences