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Uncovering the Protumourigenic Role of the ADAM17 Protease in Lung Cancer

posted on 15.05.2019, 06:18 authored by MOHAMED IBRAHIM MOHAMED AHMED SAAD
Lung adenocarcinoma is the most common form of lung cancer, the leading cause of cancer death worldwide. Mutations in the KRAS gene are the most studied causes of lung adenocarcinoma. However, the development of specific drugs inhibiting KRAS has proven challenging, and there is now a pressing need to identify new ways to inhibit KRAS. Using a series of preclinical KRAS mutant animal models, we found that the specific genetic and therapeutic inhibition of the protease ADAM17 suppressed tumour burden significantly. Our findings pave the way for the development of new drugs that can be used to treat lung adenocarcinoma.


Principal supervisor

Brendan Jenkins

Additional supervisor 1

Saleela Ruwanpura

Year of Award


Department, School or Centre

Molecular and Translational Sciences


Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences