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Reason: Under embargo until April 2021. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

UNDERSTANDING THE ROLE OF HLA-B27 IN THE PATHOGENESIS OF ANKYLOSING SPONDYLITIS

thesis
posted on 06.04.2020, 07:15 authored by TERRY CHIN CHOY LIM KAM SIAN
Ankylosing Spondylitis (AS) is an autoimmune disease which is mostly characterised by lower back pain and fusion of the vertebrae. Over 90% of AS patients express the HLA-B27 gene and the probability of disease increases during infection with gastrointestinal bacteria. In this study we look at how mutations in the HLA-B27 gene and infection with Salmonella impact of on its immunological function. We observed that inflammation due to infection drastically increase an abnormal form of HLA-B27, possibly leading to autoimmunity. The data collected in this study would also be valuable for interrogation of other Spondyloarthropathies.

History

Principal supervisor

Anthony Purcell

Additional supervisor 1

Ralf Schittenhelm

Year of Award

2020

Department, School or Centre

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences