Monash University
L157 BON TRAN Merged_Revisedthesis_Redacted.pdf (11.02 MB)
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Treatment of multidrug-resistant Acinetobacter baumannii with novel combinations of polymyxin B and other non-antibiotic drugs

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posted on 2019-03-22, 01:57 authored by THIEN BON TRAN
Multidrug-resistant Acinetobacter baumannii are increasingly becoming problematic to the healthcare system globally due to limited effective antibiotics. This thesis investigated the potential of repositioning non-antibiotic drugs for use in combination with polymyxin B to enhance the bacterial killing of this last-line antibiotic against these pathogens and prevent the emergence of polymyxin resistance. The in vitro and in vivo studies identified numerous promising non-antibiotic candidates with synergistic antimicrobial activity against multiple Gram-negative bacteria including A. baumannii. The metabolomic studies revealed potential bacterial killing mechanisms of a novel combination and transcriptomic studies discovered numerous potential targets for future repositioning of non-antibiotic drugs.


Principal supervisor

Jian Li

Additional supervisor 1

Tony Velkov

Additional supervisor 2

Phillip J Bergen

Year of Award


Department, School or Centre


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences