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Translating functional characteristics of dietary fibre to clinical value in patients with irritable bowel syndrome
thesisposted on 26.07.2021, 04:34 by DANIEL SO
Irritable bowel syndrome is a common disorder with symptoms of abdominal pain and compromised gut functioning. Some types of dietary fibre may help improve aspects of gut function but may also worsen symptoms. We identified two specific fibres, one from sugarcane and another from corn, with characteristics potentially suitable for these patients. We then showed that these fibres, when used together with a common therapeutic diet (low FODMAP diet), were well-tolerated and improved multiple aspects of gut function. Additionally, using novel technologies, we showed the fibres changed how the gut bacteria behaved in different areas of the colon.