Monash University

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Transcriptomic, proteomic and functional analysis of the plasmid pCS1-1 during spore formation in Paeniclostridium sordellii

posted on 2020-12-29, 22:40 authored by Samantha Jane Munn
Spore-forming bacteria, and the wide variety of infections they cause, have a devastating impact on human and animal health globally. Plasmid DNA often encodes factors that contribute to severe disease and antibiotic resistance. Little is known about the role of plasmid DNA in the formation of bacterial spores, and no previous studies have investigated this in the class of bacteria known as the Clostridia. Using Paeniclostridium sordellii as a model spore-forming organism, the work within this thesis focused on the toxin-encoding plasmid, pCS1-1, to investigate if plasmid DNA contributes to, or is influenced by, spore formation.


Principal supervisor

Dena Lyras

Additional supervisor 1

Yogitha Srikhanta

Year of Award


Department, School or Centre

School of Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses