Monash University

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Toxicity and anti-proliferative effects of peptidyl chloromethyl ketones in Jurkat T cells

posted on 2019-07-22, 05:43 authored by POI YEE CHEONG
This thesis examines the effects of synthetic enzyme inhibitors on a human leukemic T cell line. These inhibitors kill the cells by inducing programmed cell death at low concentrations and necrosis at higher concentrations. At non-toxic concentrations, the inhibitors stop the cells from proliferating and block cell cycle progression by preventing the cells from leaving and entering the cell cycle. All these effects are caused by oxidative stress via the production of reactive oxygen species. By understanding how these inhibitors affect these leukemic T cells may provide insights in developing more specific anticancer drugs.


Principal supervisor

Chow Sek Chuen

Year of Award


Department, School or Centre

School of Sciences (Monash University Malaysia)


Doctor of Philosophy

Degree Type



Faculty of Science