Monash University

Embargoed and Restricted Access

Reason: Under embargo until August 2019. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Towards A Novel Non-Viral Gene Delivery System Based On Adenovirus Genome

posted on 2018-08-16, 05:41 authored by HARETH BASIM ALI AL-WASSITI
Gene therapy is a new form of medical treatment that delivers genetic "information” to treat diseases. In order to achieve a good outcome, a gene delivery system must reach the appropriate location inside the target cell after administration by injection. The project examined different ways to enhance the delivery of genetic information and investigated how the information is processed to achieve the desired therapeutic outcome. New delivery technologies were explored, using mechanisms used by viruses for inspiration. The results identified new opportunities to improve the performance of gene delivery systems to treat diseases such as cancer.


Campus location


Principal supervisor

Colin Pouton

Additional supervisor 1

Dr Angus Johnston

Additional supervisor 2

Dr Charlie Dong

Year of Award


Department, School or Centre

Drug Delivery, Disposition and Dynamics

Additional Institution or Organisation

Monash Institute of Pharmaceutical Sciences


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences