Monash University

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The use of a novel IFN-γ release assay to characterise cytomegalovirus (CMV) and immunological outcomes in transplant and HIV-infected individuals

posted on 2018-05-14, 05:59 authored by MICHELLE KAREN YONG
A lowered immune system in the setting of stem cell transplantation or human immunodeficiency virus (HIV) infection places individuals at high risk of infectious and non-infectious complications. This research evaluated the clinical use of easy, rapid, high throughput immune biomarkers to predict clinical outcomes such as cytomegalovirus (CMV)-related morbidity, end organ disease and/or overall mortality. The studies in this thesis showed that these markers were able to predict infectious complications and/or death. Use of these markers will have an important impact in the health care of future individuals undergoing immunosuppression.


Principal supervisor

Sharon Lewin

Additional supervisor 1

Paul Cameron

Additional supervisor 2

Monica Slavin

Year of Award


Department, School or Centre

Medicine - Alfred

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses