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The structural and mechanistic insight into the modulation of IL-21 function

thesis
posted on 20.11.2017, 00:36 by ZHIAN CHEN
Clinical trials to target interleukin-21 (IL-21) have achieved promising results to treat cancers and infections. Modulating the bioactivity of this cytokines is, therefore, an approach to deliver a therapeutic efficacy. By crystallography methodology, I revealed the mechanism of an agonistic antibody to human IL-21, which significantly enhances the bio-activity of IL-21 ex vivo and in vivo. Also, based on this structural information, I identified a previously unknown IL-21 binding partner, which could regulate the function of IL-21 physiologically.

History

Principal supervisor

Di Yu

Year of Award

2017

Department, School or Centre

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

Exports