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Reason: Under embargo until 13 December 2024. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

The roles of activin A and Ipo5 in spermatogonial stem cell biology

thesis
posted on 2023-12-11, 23:18 authored by PENELOPE ALEXANDRA FALSHAW WHILEY
In Australia, 1 in 6 men is infertile, and in many cases, the underlying causes are unclear. Spermatogonial stem cells (SSCs) are essential for male fertility, and remarkably, they can restore spermatogenesis (the process of making viable sperm) following disruption. My thesis explored the contributions of elevated activin A and the nuclear transport factor, Importin 5, to SSC function and biology. This research highlights how inappropriate levels of activin A disrupts SSC development in both juvenile and adults, and identifies molecules important to their long-term survival.

History

Principal supervisor

Kate Loveland

Additional supervisor 1

Robin Hobbs

Additional supervisor 2

Peter Stanton

Year of Award

2023

Department, School or Centre

Clinical Sciences at Monash Health

Additional Institution or Organisation

Department of Molecular and Translational Science. Hudson Institute of Medical Research

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

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