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The roles of SOX17 and RUNX1 in the generation of haematopoietic lineages from human pluripotent stem cells

thesis
posted on 03.07.2017, 05:29 authored by FREYA FAITH BRUVERIS
Investigating the stages of human blood cell development forms the basis of this thesis. Human embryonic stem cells were used to examine the contribution of two genes in developing blood cells, SOX17 and RUNX1. The gene RUNX1 was found to be essential in the early stage, whilst SOX17 was necessary in the latter stage of blood cell development. This study provides an understanding of blood cell development in the embryo. In the future, these laboratory generated blood cells may assist in therapeutic treatments for leukaemia patients and those diagnosed with blood diseases.

History

Principal supervisor

Andrew Elefanty

Additional supervisor 1

Ed Stanley

Year of Award

2017

Department, School or Centre

Anatomy and Developmental Biology

Additional Institution or Organisation

Murdoch Children's Research Institute

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

Doctorate

Faculty

Faculty of Medicine Nursing and Health Sciences