Monash University
RM thesis revised merged v2 FINAL submitted-redacted.pdf (19.63 MB)

The role of the gut microbiota and its metabolite-sensing receptors in blood pressure regulation

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posted on 2023-09-10, 23:56 authored by RIKEISH R MURALITHARAN
Over 50% of individuals with hypertension fail to have their blood pressure under recommended target levels, highlighting the need for new treatment options. In my Thesis, I explored the role of gut bacteria and their by-product signalling in regulating blood pressure. I also investigated what factors influence the gut bacteria and how the host senses and responds to short-chain fatty acids, beneficial by-products produced by the gut bacteria. My findings confirm that gut bacteria play a crucial role in hypertension and suggest that targeting the receptors responsible for sensing short-chain fatty acids could be a promising therapeutic approach.


Campus location


Principal supervisor

Francine Marques

Additional supervisor 1

Charles R Mackay

Additional supervisor 2

Joanne O'Donnell

Year of Award


Department, School or Centre

Biological Sciences


Doctor of Philosophy

Degree Type



Faculty of Science