Monash University

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Reason: Under embargo until February 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

The role of mitochondria-targeted therapeutics to improve oocyte quality in mice and humans

posted on 2021-02-09, 04:49 authored by USAMA ISMAIL MJBEL AL-ZUBAIDI
Behind every treatment that improves fertility rate is a story of discovery. Infertility is considered one of the major global health issues. With age, egg quality is dramatically impacted, leading to some functional changes that occur during the reproductive period in women. Particularly, the providers of energy in eggs, mitochondria, lose the ability to support normal biological functions. We hypothesized aging-related defects in mitochondrial function lead to declining fertility. During the experiments, we observed that mitochondria-targeted agents pave the way to mitigate the effect of aging. Therefore, mitochondrial therapies are a promising concept to tackle decreasing fertility in aged women.


Principal supervisor

John Graham Carroll

Year of Award


Department, School or Centre

School of Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Anatomy and Developmental Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences