L100 Yeong Hann Ling PhD Thesis Final (With Revisions)_Redacted.pdf (32.51 MB)
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The role of inflammasomes, IL-1β, IL-18, and nitric oxide in inflammation and hypertension

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thesis
posted on 13.03.2019, 22:32 by YEONG HANN LING
High blood pressure affects approximately one third of the world’s adult population and contributes to heart attacks and strokes. Many patients with hypertension are not treated effectively by currently-available blood pressure lowering drugs, highlighting the need for more research to identify new treatments. We have shown that a component of the immune system known as the ‘inflammasome’ is switched on during hypertension and contributes to high blood pressure. By blocking the actions of the inflammasome with newly identified drugs, we reduced blood pressure in hypertensive mice. Hence, this project offers new hope to patients struggling to manage their blood pressure.

History

Principal supervisor

Grant Drummond

Additional supervisor 1

Barbara Kemp-Harper

Year of Award

2018

Department, School or Centre

Pharmacology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences