Embargoed and Restricted Access

Reason: Under embargo until March 2020. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

The role of complement in antibody-mediated immune mechanisms against malaria

thesis
posted on 08.03.2019, 05:22 authored by LIRIYE KURTOVIC
There are considerable challenges for developing malaria vaccines, and one of the most fundamental is our limited knowledge of the immune mechanisms that confer protection against infection and disease. Antibodies to circumsporozoite protein (CSP) demonstrate some association with protection, but it is unclear how they function. This thesis addressed these knowledge gaps, and identified that antibodies to CSP and malaria sporozoites can activate human complement. Functional antibody responses were associated with protection against malaria, and could be induced by the leading vaccine candidate, RTS,S. These findings provide key insights into the mechanisms of protective immunity, which can aid vaccine development.

History

Principal supervisor

James Beeson

Additional supervisor 1

Freya Fowkes

Year of Award

2019

Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Burnet Institute

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences