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The role of TCPTP in Mammary gland development and tumorigenesis
thesisposted on 13.03.2019, 22:47 by PEI KEE GOH
One of the drivers of triple negative breast cancer is mediated by aberrant EGFR/STAT3 signalling. The findings of this study support a model in which TCPTP deletion in mammary gland results in PTK/STAT3 hyperactivation that contributes to pre-malignant changes. Despite the pro-tumorigenic effects, the findings in this study also define a role for TCPTP to harness the host immune system to potentially impede tumour progression. The results presented in this study are the first to explore the dichotomous roles of TCPTP in tumorigenesis and its interactions with the immune system.