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The role of NF-kappaB transcription factors in Virtual Memory (Tvm) CD8+ T cells

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posted on 26.02.2020, 00:06 by DARCY PAUL ELLIS
This thesis investigates the influence of the NF-kappaB transcription factors in a subset of CD8+ T cells, termed virtual memory cells. Virtual memory cells are T cells that have become activated and acquired enhanced immune functions through mechanisms that normally act to maintain homeostasis of the immune system. NF-kappaB transcription factors are a collection of proteins that function to turn on and off genes. This investigation shows that a member of the NF-kappaB family, RelA, plays an important role in regulating genes in virtual memory cells that are important for their development, function and homeostatic maintenance.


Principal supervisor

Steven Gerondakis

Additional supervisor 1

Robyn Slattery

Year of Award


Department, School or Centre

Biochemistry and Molecular Biology

Campus location



Doctor of Philosophy

Degree Type


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