Ellis_ThesisFinal0220.pdf (3.72 MB)
0/0

The role of NF-kappaB transcription factors in Virtual Memory (Tvm) CD8+ T cells

Download (3.72 MB)
thesis
posted on 26.02.2020 by DARCY PAUL ELLIS
This thesis investigates the influence of the NF-kappaB transcription factors in a subset of CD8+ T cells, termed virtual memory cells. Virtual memory cells are T cells that have become activated and acquired enhanced immune functions through mechanisms that normally act to maintain homeostasis of the immune system. NF-kappaB transcription factors are a collection of proteins that function to turn on and off genes. This investigation shows that a member of the NF-kappaB family, RelA, plays an important role in regulating genes in virtual memory cells that are important for their development, function and homeostatic maintenance.

History

Principal supervisor

Steven Gerondakis

Additional supervisor 1

Robyn Slattery

Year of Award

2020

Department, School or Centre

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Exports

Exports