The role of INPP4B overexpression in breast cancer pathogenesis

Breast cancer is the predominant form of cancer among females, with one in eight women likely to develop this disease in their lifetime. The protein INPP4B is a tumour suppressor that is lost in a subset of breast cancers, leading to increased tumour growth. However, the findings in this thesis show that INPP4B levels are increased in a different subset of breast cancers with poorer prognosis. Paradoxically, INPP4B overexpression was found to promote tumour growth via a previously uncharacterised signalling mechanism. These findings could lead to the development of novel therapeutic strategies for breast cancers.