The role of Hfq and sRNAs in regulation of Pasteurella multocida gene expression
thesisposted on 27.05.2020, 07:47 by MARIANNE NELLY FLEURETTE MEGROZ
The bacterium Pasteurella multocida is the cause of numerous economically important animal diseases, including avian fowl cholera. Little is known about the regulation of genes involved in P. multocida virulence. Hfq is a bacterial chaperone protein that can facilitate important RNA-RNA regulatory functions, usually via small RNA (sRNA) molecules. In this study, we aimed to unravel the role of the Hfq protein and sRNAs in the P. multocida regulatory network specifically focusing on functions that impact P. multocida pathogenesis. By increasing our understanding of the regulation of P. multocida virulence, we can develop therapeutic agents to treat P. multocida infections.