Monash University

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Reason: Under embargo until February 2019. After this date a copy can be supplied under Section 51 (2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

The role of DNA methylation in Obesity and Diabetes

posted on 2018-02-13, 01:38 authored by ISHANT KHURANA
A significant proportion of human disease causality remains unexplained. It is increasingly becoming clear that Epigenetics is a key contributor to many diseases, including cardiovascular diseases, atherosclerosis and diabetes. Epigenetics refers to the external modification to DNA that turn genes “ON” and “OFF”. These modifications do not change the DNA sequence, but instead, they effect cells ability to “read” genes. This thesis investigates the role of DNA methylation in Obesity and Diabetes.


Principal supervisor

Assam El-Osta

Additional supervisor 1

Mark Ziemann

Year of Award


Department, School or Centre

Central Clinical School

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences