The role of ChREBP in insulin resistance and hepatic lipid metabolism

Obesity is associated with the development of various metabolic diseases. This research centers on ChREBP; a protein involved in glucose and lipid metabolism; and aimed to define its involvement in the development of fatty liver and insulin resistance. Utilizing various mouse models we found ChREBP has a clear role in regulating fatty liver, glucose homeostasis and liver insulin sensitivity. Overall, liver ChREBP is critical in maintaining glucose homeostasis and liver insulin sensitivity despite promoting fatty liver. Therefore, ChREBP may be important in the development of hyperglycemia and diabetes, and elucidating the mediators involved may uncover novel targets for therapeutic development.