L14 PinaresGarciaPauloPhDThesis10January2019_Redacted.pdf (23.94 MB)
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The regulation and function of the Y chromosome gene, SRY, in experimental and clinical PD

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thesis
posted on 12.03.2019 by PAULO CESAR PINARES-GARCIA
Parkinson’s disease (PD) is a debilitating neurodegenerative disorder that results from the death of dopamine-producing cells in the brain. Whilst the cause of PD is unknown, the male-sex is a significant risk factor. My thesis investigated whether the Y-chromosome gene, SRY, contributes to the vulnerability of males to PD. I found that SRY expression is dysregulated in experimental and clinical PD, and that reducing SRY expression can slow the disease progression in multiple animal models of PD. Overall, work from my thesis reveal a novel sex-specific cause for PD and that SRY may be novel therapeutic target for PD.

History

Principal supervisor

Joohyung Lee

Additional supervisor 1

Vincent Harley

Year of Award

2019

Department, School or Centre

Anatomy and Developmental Biology

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

Categories

Exports