L14 PinaresGarciaPauloPhDThesis10January2019_Redacted.pdf (23.94 MB)
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The regulation and function of the Y chromosome gene, SRY, in experimental and clinical PD

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posted on 12.03.2019, 00:58 by PAULO CESAR PINARES-GARCIA
Parkinson’s disease (PD) is a debilitating neurodegenerative disorder that results from the death of dopamine-producing cells in the brain. Whilst the cause of PD is unknown, the male-sex is a significant risk factor. My thesis investigated whether the Y-chromosome gene, SRY, contributes to the vulnerability of males to PD. I found that SRY expression is dysregulated in experimental and clinical PD, and that reducing SRY expression can slow the disease progression in multiple animal models of PD. Overall, work from my thesis reveal a novel sex-specific cause for PD and that SRY may be novel therapeutic target for PD.


Principal supervisor

Joohyung Lee

Additional supervisor 1

Vincent Harley

Year of Award


Department, School or Centre

Anatomy and Developmental Biology

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences

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